Graduate Research Thesis, UCL / The Alan Turing Institute
Jan 2025 - Oct 2025
- Identified biological plausibility gaps in spatial transcriptomics generation from histology on HEST-1K breast cancer data.
- Developed a biologically constrained LUPI framework using matched bulk RNA-seq during training while preserving H and E-only inference.
- Built a multi-objective validation pipeline covering SSIM, GSVA pathway correlation, Moran's I, cell-type deconvolution, and gene-category analysis.